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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/288002
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- Title
- An Oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and ¹⁹F MRI oximetry
- Related
- Magnetic resonance materials in physics, biology and medicine, Vol. 23, Issue 4, (2010), p.217-226
- DOI
- 10.1007/s10334-010-0219-6
- Publisher
- Springer
- Date
- 2010
- Author/Creator
- Baete, Steven H
- Author/Creator
- Vandecasteele, Jan
- Author/Creator
- Colman, Luc
- Author/Creator
- De Neve, Wilfried
- Author/Creator
- De Deene, Yves
- Description
- Objective: This study presents a reproducible phantom which mimics oxygen-consuming tissue and can be used for the validation of ¹⁹F MRI oximetry. Materials and methods: The phantom consists of a haemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells. Perfluorocarbon emulsions can be added to the gelatin matrix to simulate sequestered perfluorocarbons. A blood-substituting perfluorocarbon fluid is pumped through the lumen of the fibres in the filter. ¹⁹F relaxometry MRI is performed with a fast 2D Look-Locker imaging sequence on a clinical 3T scanner. Results: Acute and perfusion-related hypoxia were simulated and imaged spatially and temporally using the phantom. Conclusions: The presented experimental setup can be used to simulate oxygen consumption by somatic cells in vivo and for validating computational biophysical models of hypoxia, as measured with ¹⁹F MRI oximetry.
- Description
- 10 page(s)
- Subject Keyword
- 090300 Biomedical Engineering
- Subject Keyword
- ¹⁹F MRI oximetry
- Subject Keyword
- Fast T1-imaging
- Subject Keyword
- Phantom
- Subject Keyword
- Quantitative magnetic resonance imaging (qMRI)
- Subject Keyword
- Tumour hypoxia
- Resource Type
- journal article
- Organisation
- Macquarie University. Department of Engineering
- Identifier
- http://hdl.handle.net/1959.14/288002
- Identifier
- mq:30896
- Identifier
- ISSN:0968-5243
- Identifier
- mq-rm-2013002350
- Identifier
- mq_res-ext-2-s2.0-77956413977
- Language
- eng
- Reviewed
Macquarie University ResearchOnline
