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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/334892
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- Title
- Evidence for dysregulated high-frequency oscillations during sensory processing in medication-naïve, first episode schizophrenia
- Related
- Schizophrenia research, Vol. 150, No. 2-3, (2013), p.519-525
- DOI
- 10.1016/j.schres.2013.08.023
- Publisher
- Elsevier
- Date
- 2013
- Author/Creator
- Sun, Limin
- Author/Creator
- Castellanos, Nazareth
- Author/Creator
- Grützner, Christine
- Author/Creator
- Koethe, Dagmar
- Author/Creator
- Rivolta, Davide
- Author/Creator
- Wibral, Michael
- Author/Creator
- Kranaster, Laura
- Author/Creator
- Singer, Wolf
- Author/Creator
- Leweke, Marcus F
- Author/Creator
- Uhlhaas, Peter J
- Description
- Introduction: High-frequency oscillations are important for sensory processing and dysfunctions in the amplitude and synchrony of beta- and gamma-band oscillations have been demonstrated in schizophrenia (ScZ). However, the presence of aberrant high-frequency oscillations in first-episode (FE), medication-naive patients during sensory processing is unclear. Methods: Magnetoencephalographic (MEG) data were recorded from 15 never-medicated, FE-ScZ patients and 20 matched healthy controls during the perception of Mooney faces. MEG data were analysed for spectral power and single-sensor phase-locking in the beta (13-25 Hz) and gamma- (25-140 Hz) frequency range. Results: FE-ScZ patients were characterized by significantly impaired sensory processing as indicated by a reduced discrimination index (A'). Impaired behavioural performance in ScZ-patients was accompanied by decreased spectral power in the high- (60-120 Hz) gamma-band range. In contrast, oscillations in the lower (25-60 Hz) gamma-band were largely intact and beta-band oscillations were increased. Analysis of cross-frequency coupling showed a reduced correlation between 60 and 120 Hz amplitude values and beta-band power in FE-ScZ-patients relative to controls. Discussion: Our findings show that impaired sensory processing in medication-naive, FE-schizophrenia is related to a dysregulation of neural oscillations which involves both an impairment in the generation of high gamma-band activity as well as a failure to downregulate task-irrelevant beta-band activity. Because of the interrelationship of these dysfunctions and the role of inhibitory networks in the shaping of high-frequency activity, aberrant neural oscillations in FE-schizophrenia may be linked to dysfunctions in the excitation-inhibition (E/I)-balance.
- Description
- 7 page(s)
- Subject Keyword
- First-episode
- Subject Keyword
- High-frequency oscillations
- Subject Keyword
- MEG
- Subject Keyword
- Neural synchrony
- Subject Keyword
- Perceptual organization
- Subject Keyword
- Schizophrenia
- Resource Type
- journal article
- Organisation
- Macquarie University. Department of Cognitive Science
- Identifier
- http://hdl.handle.net/1959.14/334892
- Identifier
- mq:37052
- Identifier
- ISSN:0920-9964
- Identifier
- mq-rm-2013009759
- Identifier
- mq_res-ext-2-s2.0-84886287924
- Language
- eng
- Reviewed
Macquarie University ResearchOnline
