Genomic classification of cutaneous melanoma

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/1062489

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Title: Genomic classification of cutaneous melanoma
Related: Cell, Vol. 161, Issue 7, (2015), p.1681-1696
DOI: 10.1016/j.cell.2015.05.044
Publisher: Cell Press
Date: 2015
Author/Creator: Akbani, Rehan
Author/Creator: Akdemir, Kadir C
Author/Creator: Baboud, Julien
Author/Creator: Gomez-Fernandez, Carmen
Author/Creator: Gribbin, Thomas
Author/Creator: Grimsby, Jonna
Author/Creator: Gross, Benjamin
Author/Creator: Guin, Ranabir
Author/Creator: Gutschner, Tony
Author/Creator: Hadjipanayis, Angela
Author/Creator: Halaban, Ruth
Author/Creator: Hanf, Benjamin
Author/Creator: Haussler, David
Author/Creator: Balasundaram, Miruna
Author/Creator: Haydu, Lauren E
Author/Creator: Hayes, D. Neil
Author/Creator: Hayward, Nicholas K
Author/Creator: Heiman, David I
Author/Creator: Herbert, Lynn
Author/Creator: Herman, James G
Author/Creator: Hersey, Peter
Author/Creator: Hoadley, Katherine A
Author/Creator: Hodis, Eran
Author/Creator: Holt, Robert A
Author/Creator: Balu, Saianand
Author/Creator: Hoon, Dave S. B
Author/Creator: Hoppough, Susan
Author/Creator: Hoyle, Alan P
Author/Creator: Huang, Franklin W
Author/Creator: Huang, Mei
Author/Creator: Huang, Sharon
Author/Creator: Hutter, Carolyn M
Author/Creator: Ibbs, Matthew
Author/Creator: Iype, Lisa
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Author/Creator: Ju, Zhenlin
Author/Creator: Kakavand, Hojabr
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Author/Creator: Bartlett, John
Author/Creator: Kefford, Richard F
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Author/Creator: Korkut, Anil
Author/Creator: Korski, Konstanty
Author/Creator: Krauthammer, Michael
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Author/Creator: Kwong, Lawrence N
Author/Creator: Bartlett, Pam
Author/Creator: Kycler, Witold
Author/Creator: Ladanyi, Marc
Author/Creator: Lai, Phillip H
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Author/Creator: Łaźniak, Radoslaw
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Author/Creator: Lee, Jeffrey E
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Author/Creator: Parker, Joel S
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Author/Creator: Deribe, Yonathan Lissanu
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Author/Creator: Getz, Gad
Description: We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multidimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.
Description: 16 page(s)
Resource Type: journal article
Organisation: Macquarie University. Department of Clinical Medicine

Identifier: http://hdl.handle.net/1959.14/1062489
Identifier: mq:43619
Identifier: ISSN:0092-8674
Identifier: mq-rm-2014002175
Identifier: mq_res-se-548217
Language: eng
Reviewed

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