Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Macquarie University ResearchOnline

Home
Show All
Show Quick Collection
Highlights +
Most Accessed Papers Recent Additions
Pending Publications
Open Access
Copyright
Contact Us

Home

List Of Titles

Add to Quick Collection

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/1070416

13491 Visitors

16007 Hits

0 Downloads

Title: Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Related: Nature genetics, Vol. 47, Issue 9, (2015), p.987-995
DOI: 10.1038/ng.3373
Publisher: Nature Publishing Group
Date: 2015
Author/Creator: Law, Matthew H
Author/Creator: Bishop, D. Timothy
Author/Creator: Pharoah, Paul D. P
Author/Creator: Vilalta, Antonio
Author/Creator: Calista, Donato
Author/Creator: Landi, Giorgio
Author/Creator: Minghetti, Paola
Author/Creator: Arcangeli, Fabio
Author/Creator: Bertazzi, Pier Alberto
Author/Creator: Pastorino, Lorenza
Author/Creator: Bruno, William
Author/Creator: Andreotti, Virginia
Author/Creator: Martinuzzi, Claudia
Author/Creator: Swerdlow, Anthony J
Author/Creator: Battistuzzi, Linda
Author/Creator: Origone, Paola
Author/Creator: Queirolo, Paola
Author/Creator: Affleck, Paul
Author/Creator: Harrison, Jane
Author/Creator: Whittaker, Linda
Author/Creator: Kukalizch, Kairen
Author/Creator: Leake, Susan
Author/Creator: Karpavicius, Birute
Author/Creator: Haynes, Sue
Author/Creator: Kypreou, Katerina P
Author/Creator: Mack, Tricia
Author/Creator: Chan, May
Author/Creator: Taylor, Yvonne
Author/Creator: Davies, John
Author/Creator: King, Paul
Author/Creator: van Nieuwpoort, Frans A
Author/Creator: Out, Coby
Author/Creator: van der Drift, Clasine
Author/Creator: Bergman, Wilma
Author/Creator: Kukutsch, Nicole
Author/Creator: Taylor, John C
Author/Creator: Bouwes Bavinck, Jan Nico
Author/Creator: Bakker, Bert
Author/Creator: ter Huurne, Jeanet
Author/Creator: van der Rhee, Han
Author/Creator: Bekkenk, Marcel
Author/Creator: Snels, Dyon
Author/Creator: van Praag, Marinus
Author/Creator: Brochez, Lieve
Author/Creator: Gerritsen, Rianne
Author/Creator: Crijns, Marianne
Author/Creator: Harland, Mark
Author/Creator: Vasen, Hans
Author/Creator: van Workum, Wilbert
Author/Creator: Janssen, Bart
Author/Creator: Janssen, Marjolein
Author/Creator: Mulder, Suzanne
Author/Creator: Jönsson, Göran
Author/Creator: Borg, Åke
Author/Creator: Måsbäck, Anna
Author/Creator: Lundgren, Lotta
Author/Creator: Baeckenhorn, Katja
Author/Creator: Randerson-Moor, Juliette
Author/Creator: Nielsen, Kari
Author/Creator: Schmidt Casslén, Anita
Author/Creator: Rootwelt, Helge
Author/Creator: Bressac-de Paillerets, Brigitte
Author/Creator: Maubec, Eve
Author/Creator: Brossard, Myriam
Author/Creator: Vaysse, Amaury
Author/Creator: Mohamdi, Hamida
Author/Creator: Jeannin, Patricia
Author/Creator: Chaudru, Valérie
Author/Creator: Akslen, Lars A
Author/Creator: Chateigner, Nicolas
Author/Creator: Corda, Eve
Author/Creator: Lesueur, Fabienne
Author/Creator: de Lichy, Mahaut
Author/Creator: Andry-Benzaquen, Pascale
Author/Creator: Bachollet, Bertrand
Author/Creator: Bérard, Frédéric
Author/Creator: Berthet, Pascaline
Author/Creator: Boitier, Françoise
Author/Creator: Bonadona, Valérie
Author/Creator: Andresen, Per A
Author/Creator: Bonafé, Jean-Louis
Author/Creator: Bonnetblanc, Jean-Marie
Author/Creator: Cambazard, Frédéric
Author/Creator: Caron, Olivier
Author/Creator: Caux, Frédéric
Author/Creator: Chevrant-Breton, Jacqueline
Author/Creator: Chompret, Agnès
Author/Creator: Dalle, Stéphane
Author/Creator: Demange, Liliane
Author/Creator: Dereure, Olivier
Author/Creator: Avril, Marie-Françoise
Author/Creator: Doré, Martin-Xavier
Author/Creator: Doutre, Marie-Sylvie
Author/Creator: Dugast, Catherine
Author/Creator: Faivre, Laurence
Author/Creator: Grange, Florent
Author/Creator: Humbert, Philippe
Author/Creator: Joly, Pascal
Author/Creator: Kerob, Delphine
Author/Creator: Lasset, Christine
Author/Creator: Leccia, Marie Thérèse
Author/Creator: Azizi, Esther
Author/Creator: Lenoir, Gilbert
Author/Creator: Leroux, Dominique
Author/Creator: Levang, Julien
Author/Creator: Lipsker, Dan
Author/Creator: Mansard, Sandrine
Author/Creator: Martin, Ludovic
Author/Creator: Martin-Denavit, Tanguy
Author/Creator: Mateus, Christine
Author/Creator: Michel, Jean-Loïc
Author/Creator: Morel, Patrice
Author/Creator: Lee, Jeffrey E
Author/Creator: Bianchi Scarrà, Giovanna
Author/Creator: Olivier-Faivre, Laurence
Author/Creator: Perrot, Jean-Luc
Author/Creator: Robert, Caroline
Author/Creator: Ronger-Savle, Sandra
Author/Creator: Sassolas, Bruno
Author/Creator: Souteyrand, Pierre
Author/Creator: Stoppa-Lyonnet, Dominique
Author/Creator: Thomas, Luc
Author/Creator: Vabres, Pierre
Author/Creator: Wierzbicka, Eva
Author/Creator: Brown, Kevin M
Author/Creator: Knorr, Jilian
Author/Creator: Ming, Michael
Author/Creator: Mitra, Nandita
Author/Creator: Ruffin, Althea
Author/Creator: Van Belle, Patricia
Author/Creator: Lubiński, Jan
Author/Creator: Mirecka, Aneta
Author/Creator: Ertmański, Sławomir
Author/Creator: Hocevar, Marko
Author/Creator: Peric, Barbara
Author/Creator: Dȩbniak, Tadeusz
Author/Creator: Cerkovnik, Petra
Author/Creator: Kefford, Richard F
Author/Creator: Schmid, Helen
Author/Creator: Holland, Elizabeth A
Author/Creator: Galore-Haskel, Gilli
Author/Creator: Baron-Epel, Orna
Author/Creator: Scope, Alon
Author/Creator: Pavlotsky, Felix
Author/Creator: Yakobson, Emanuel
Author/Creator: Cohen-Manheim, Irit
Author/Creator: Duffy, David L
Author/Creator: Laitman, Yael
Author/Creator: Milgrom, Roni
Author/Creator: Shimoni, Iris
Author/Creator: Kozlovaa, Evgeniya
Author/Creator: Aitken, Joanne F
Author/Creator: Armstrong, Bruce K
Author/Creator: Giles, Graham G
Author/Creator: Hopper, John L
Author/Creator: Jenkins, Mark A
Author/Creator: Visscher, Peter
Author/Creator: Elder, David E
Author/Creator: Webb, Penny
Author/Creator: Green, Adele
Author/Creator: Parsons, Peter
Author/Creator: Purdie, David
Author/Creator: Zhao, Zhen Zhen
Author/Creator: Henders, Anjali K
Author/Creator: Stark, Mitchell
Author/Creator: Painter, Jodie N
Author/Creator: Pavey, Sandra
Author/Creator: Gotley, David
Author/Creator: Fang, Shenying
Author/Creator: Smithers, Mark
Author/Creator: Drew, Paul
Author/Creator: Jamieson, Glyn
Author/Creator: Watson, David
Author/Creator: Clouston, Andrew
Author/Creator: Nancarrow, D
Author/Creator: Hussey, D
Author/Creator: Smith, E
Author/Creator: Mayne, G
Author/Creator: O'Brien, S
Author/Creator: Friedman, Eitan
Author/Creator: Sadkowsky, T
Author/Creator: McMurtrie, A
Author/Creator: Terry, L
Author/Creator: Connard, M
Author/Creator: Jackman, L
Author/Creator: Perry, S
Author/Creator: Davis, M
Author/Creator: Roffe, D
Author/Creator: Martin, M
Author/Creator: Smith, L
Author/Creator: Galan, Pilar
Author/Creator: Brown, I
Author/Creator: Walker, N
Author/Creator: Bessell, Justin
Author/Creator: Tam, William
Author/Creator: Ruskowicz, Andrew
Author/Creator: Hemminki, Kari
Author/Creator: Sucker, Antje
Author/Creator: Vogt, Thomas
Author/Creator: Gutzmer, Ralf
Author/Creator: Gogas, Helen
Author/Creator: Ghiorzo, Paola
Author/Creator: Hoon, David
Author/Creator: Nagore, Eduardo
Author/Creator: Kirkwood, John
Author/Creator: Weide, Benjamin
Author/Creator: Rutkowski, Piotr
Author/Creator: Ugurel, Selma
Author/Creator: Karagianni, Fani
Author/Creator: Antonopoulou, Kyriaki
Author/Creator: Polydorou, Dorothea
Author/Creator: Hasapi, Vasiliki
Author/Creator: Gillanders, Elizabeth M
Author/Creator: Plaka, Michaela
Author/Creator: Gousetti, Nelli
Author/Creator: Papadopoulos, Othon
Author/Creator: Antoniou, Christina
Author/Creator: Evangelou, Vangelis
Author/Creator: Brossard, Myriam
Author/Creator: Goldstein, Alisa M
Author/Creator: Gruis, Nelleke A
Author/Creator: Hansson, Johan
Author/Creator: Helsing, Per
Author/Creator: Hočevar, Marko
Author/Creator: Höiom, Veronica
Author/Creator: Ingvar, Christian
Author/Creator: Kanetsky, Peter A
Author/Creator: Chen, Wei V
Author/Creator: Landi, Maria Teresa
Author/Creator: Martin, Nicholas G
Author/Creator: Lang, Julie
Author/Creator: Lathrop, G. Mark
Author/Creator: Lubiński, Jan
Author/Creator: Mackie, Rona M
Author/Creator: Mann, Graham J
Author/Creator: Molven, Anders
Author/Creator: Montgomery, Grant W
Author/Creator: Novaković, Srdjan
Author/Creator: Olsson, Håkan
Author/Creator: Puig, Susana
Author/Creator: Moses, Eric K
Author/Creator: Puig-Butille, Joan Anton
Author/Creator: Qureshi, Abrar A
Author/Creator: Radford-Smith, Graham L
Author/Creator: van der Stoep, Nienke
Author/Creator: van Doorn, Remco
Author/Creator: Whiteman, David C
Author/Creator: Craig, Jamie E
Author/Creator: Schadendorf, Dirk
Author/Creator: Simms, Lisa A
Author/Creator: Burdon, Kathryn P
Author/Creator: Song, Fengju
Author/Creator: Nyholt, Dale R
Author/Creator: Pooley, Karen A
Author/Creator: Orr, Nick
Author/Creator: Stratigos, Alexander J
Author/Creator: Cust, Anne E
Author/Creator: Ward, Sarah V
Author/Creator: Hayward, Nicholas K
Author/Creator: Han, Jiali
Author/Creator: Schulze, Hans-Joachim
Author/Creator: Dunning, Alison M
Author/Creator: Barrett, Jennifer H
Author/Creator: Newton Bishop, Julia A
Author/Creator: Demenais, Florence
Author/Creator: Amos, Christopher I
Author/Creator: MacGregor, Stuart
Author/Creator: Iles, Mark M
Author/Creator: Aguilera, Paula
Author/Creator: Alejo, Beatriz
Author/Creator: Badenas, Celia
Author/Creator: Caño, Abel
Author/Creator: Carrera, Cristina
Author/Creator: Kumar, Rajiv
Author/Creator: Cuellar, Francisco
Author/Creator: Dominguez, Mireia
Author/Creator: Gabriel, Daniel
Author/Creator: Gimenez-Xavier, Pol
Author/Creator: Iglesias, Pablo
Author/Creator: Malvehy, Josep
Author/Creator: Marti-Laborda, Rosa
Author/Creator: Mila, Montse
Author/Creator: Ogbah, Zighe
Author/Creator: Potrony, Miriam
Author/Creator: Easton, Douglas F
Author/Creator: Tell, Gemma
Author/Creator: Alós, Llúcia
Author/Creator: Arance, Ana
Author/Creator: Arguís, Pedro
Author/Creator: Bennassar, Antonio
Author/Creator: Chirife, Oscar
Author/Creator: Conill, Carlos
Author/Creator: Rull, Ramon
Author/Creator: Sánchez, Marcelo
Author/Creator: Vidal-Sicart, Sergi
Description: Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.
Description: 9 page(s)
Resource Type: journal article
Organisation: Macquarie University. Department of Clinical Medicine

Identifier: http://hdl.handle.net/1959.14/1070416
Identifier: mq:44574
Identifier: ISSN:1061-4036
Identifier: mq-rm-2014003095
Identifier: mq_res-se-550561
Language: eng
Reviewed

ABN 90 952 801 237 | CRICOS Provider No 00002J