Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/1070416

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Title: Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Related: Nature genetics, Vol. 47, Issue 9, (2015), p.987-995
DOI: 10.1038/ng.3373
Publisher: Nature Publishing Group
Date: 2015
Author/Creator: Law, Matthew H
Author/Creator: Bishop, D. Timothy
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Author/Creator: Rull, Ramon
Author/Creator: Sánchez, Marcelo
Author/Creator: Vidal-Sicart, Sergi
Description: Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.
Description: 9 page(s)
Resource Type: journal article
Organisation: Macquarie University. Department of Clinical Medicine

Identifier: http://hdl.handle.net/1959.14/1070416
Identifier: mq:44574
Identifier: ISSN:1061-4036
Identifier: mq-rm-2014003095
Identifier: mq_res-se-550561
Language: eng
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