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Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/279699
Description: Purpose. 3-Hydroxykynurenine O-β-D-glucoside (3OHKG) protects the lens from UV damage, and novel related species may act analogously. The aim of this study was to detect, quantify, and elucidate the s ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295639
Description: Objective: Carnosine has been shown to modulate triglyceride and glycation levels in cell and animal systems. In this study we investigated whether prolonged supplementation with carnosine inhibits at ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/176392
Description: Since crystallins in the human lens do not turnover, they are susceptible to modification by reactive molecules over time. Methylation is a major post-translational lens modification, however the sour ... More
Reviewed: Reviewed
Date: 2008
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/180243
Description: Objective— Oxidized lipids and proteins, as well as decreased antioxidant levels, have been detected in human atherosclerotic lesions, with oxidation catalyzed by iron and copper postulated to contrib ... More
Reviewed: Reviewed
Date: 2008
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1153989
Description: The human eye is chronically exposed to light of wavelengths > 300 nm. In the young human lens, light of wavelength 300-400 nm is predominantly absorbed by the free Trp derivatives kynurenine (Kyn), 3 ... More
Reviewed: Reviewed
Date: 2007
Subject Keyword: 030500 Organic Chemistry
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/22018
Description: 4-(2-Aminophenyl)-4-oxobutanoic acid, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid and glutathionyl-kynurenine have been identified as novel metabolites in normal and cataractous human lenses follow ... More
Reviewed: Reviewed
Date: 2007
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/22028
Description: PURPOSE. Human ultraviolet light (UV) filters, such as kynurenine (Kyn), readily deaminate to reactive unsaturated ketones that covalently modify proteins in older human lenses. The aim of this study ... More
Reviewed: Reviewed
Date: 2007
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1225034
Description: 1 page(s)
Date: 2006
Subject Keyword: UV filter | cataract | human lens
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/25857
Description: The primate lens contains fluorescent tryptophan derived compounds known as UV filters. These absorb UV light and protect the lens from UV induced photo-damage. The major UV filters are 3-hydroxykynur ... More
Date: 2006
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/25047
Date: 2004
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1231759
Description: 1 page(s)
Date: 2004
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1231831
Description: 1 page(s)
Date: 2004
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/19064
Description: uman lens proteins become progressively modified by tryptophan-derived UV filter compounds in an age-dependent manner. One of these compounds, kynurenine, undergoes deamination at physiological pH, an ... More
Reviewed: Reviewed
Date: 2004
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1232135
Description: 1 page(s)
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