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Add  Characterization of monomeric and multimeric snake neurotoxins and other bioactive proteins from the venom of the lethal Australian common copperhead (Austrelaps superbus)
Authors: Marcon, Francesca | Purtell, Louise | Santos, Jerran | Hains, Peter G | Escoubas, Pierre | Graudins, Andis | Nicholson, Graham M
Date: 2013
Subject Keyword: A₂ neurotoxin | Australian copperhead | Mass fragmentation | Snake antivenom | Snake presynaptic phospholipase | Snake toxin
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/269619
Description: Envenomation by Australian copperheads results mainly in muscle paralysis largely attributed to the presence of postsynaptic α-neurotoxins. However, poorly reversible neurotoxic effects suggest that t ... More
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Add  Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photo sensitizers of oxidative damage
Authors: Mizdrak, Jasminka | Hains, Peter G | Truscott, Roger J W | Jamie, Joanne F | Davies, Michael J
Date: 2008
Subject Keyword: 030400 Medicinal and Biomolecular Chemistry | 3,4-Dihydroxyphenylalanine | 3-Hydroxykynurenine | UV damage | 3-Hydroxykynurenine-O-β-D-glucoside | Cataract | Cross-link | Di-tyrosine | Hydrogen peroxide | Lens | Photooxidation | Singlet oxygen
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1153989
Description: The human eye is chronically exposed to light of wavelengths > 300 nm. In the young human lens, light of wavelength 300-400 nm is predominantly absorbed by the free Trp derivatives kynurenine (Kyn), 3 ... More
Reviewed: Reviewed
Add  Novel human lens metabolites from normal and cataractous human lens
Authors: Mizdrak, Jasminka | Hains, Peter G | Kalinowski, Danuta | Truscott, Roger J. W | Davies, Michael J | Jamie, Joanne F
Date: 2007
Subject Keyword: 030500 Organic Chemistry
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/22018
Description: 4-(2-Aminophenyl)-4-oxobutanoic acid, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid and glutathionyl-kynurenine have been identified as novel metabolites in normal and cataractous human lenses follow ... More
Reviewed: Reviewed
Add  Human lens chemistry - UV filters and cataract
Authors: Mizdrak, Jasminka | Hains, Peter G | Truscott, Roger J. W | Davies, Michael J | Jamie, Joanne F
Date: 2006
Subject Keyword: UV filter | cataract | human lens
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/25857
Description: The primate lens contains fluorescent tryptophan derived compounds known as UV filters. These absorb UV light and protect the lens from UV induced photo-damage. The major UV filters are 3-hydroxykynur ... More
Add  Human lens chemistry : novel UV filters
Authors: Mizdrak, Jasminka | Hains, Peter G | Truscott, Roger J. W | Davies, Michael J | Jamie, Joanne F
Date: 2006
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/25047
Add  Identification of the new UV filter compound cysteine-L-3-hydroxkynurenine O-β-D-glucoside in human lenses
Authors: Hains, Peter G | Mizdrak, Jasminka | Streete, Isla M | Jamie, Joanne F | Truscott, Roger J. W
Date: 2006
Subject Keyword: 060100 Biochemistry and Cell Biology | UV filters | cysteine | lens | cataract
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/9201
Description: UV filters protect the human lens and retina from UV light-induced damage. Here, we report the identification of a new UV filter, cysteine-l-3-hydroxykynurenine O-β-d-glucoside, which is present in ol ... More
Reviewed: Reviewed
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