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Authors:
Lewis, Katherine E
| Rasmussen, Anna L
| Bennett, William
| King, Anna
| West, Adrian K
| Chung, Roger S
| Chuah, Meng Inn
Date: 2014
Subject Keyword:
Amyotrophic lateral sclerosis
| Arginase1
| Cervical spinal cord
| Inducible nitric oxide synthase
| Lumbar spinal cord
| Microglia
| Motor neurons
| Neuroinflammation
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/325241
Description:
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the motor system. Although the etiology of the disease is not fully understood, microglial activation and
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Date: 2012
Subject Keyword:
110300 Clinical Sciences
| Brain
| Liver
| MT-I/II-knockout mice
| MT-IIA injection
| Urinary system
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/218798
Description:
Metallothionein-I/II (MT-I/II) is a small metal-binding protein with antioxidant and neuroprotective properties, which has been used experimentally as a neurotherapeutic agent in multiple conditions.
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Authors:
Leung, Jacqueline Y. K
| Bennett, William R
| Herbert, Rosalind P
| West, Adrian K
| Lee, Philip R
| Wake, Hiroaki
| Fields, R. Douglas
| Chuah, Meng Inn
| Chung, Roger S
Date: 2012
Subject Keyword:
110900 Neurosciences
| Dorsal root ganglion neurons
| Megalin
| Metallothionein
| Neurite sprouting
| Neuronal injury
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/218718
Description:
Prior studies have reported that metallothionein I/II (MT) promote regenerative axonal sprouting and neurite elongation of a variety of central nervous system neurons after injury. In this study, we e
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Authors:
Ng, Jian Ming Jeremy
| Chen, Minghui Jessica
| Cheung, Steve Nam Sang
| Chung, Roger S
| Leung, Jacqueline Y. K
| Peng, Zhao Feng
| Manikandan, Jayapal
| Qi, Robert Z
| Chuah, Meng Inn
| West, Adrian K
| Vickers, James C
| Lu, Jia
Date: 2012
Subject Keyword:
110900 Neurosciences
| Axotomy
| Microarray
| Neurite cytoskeleton
| Neurons
| Regeneration
| Secondary processes
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/218713
Description:
Axotomized neurons have the innate ability to undergo regenerative sprouting but this is often impeded by the inhibitory central nervous system environment. To gain mechanistic insights into the key m
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Authors:
Hale, David M
| Ray, Shannon
| Leung, Jacqueline Y
| Holloway, Adele F
| Chung, Roger S
| West, Adrian K
| Chuah, Meng Inn
Date: 2011
Subject Keyword:
110900 Neurosciences
| Activation of astrocytes
| Inflammation
| Microglia
| Nuclear factor kappaB
| Olfactory ensheathing cells
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/224812
Description:
Nuclear factor kappaB (NFκB) is a key transcriptional regulator of inflammatory genes. We investigated the modulatory effects of olfactory ensheathing cells (OECs), microglia and meningeal fibroblasts
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Authors:
Woodhouse, Adele
| Vincent, Adele J
| Kozel, Marie A
| Chung, Roger S
| Waite, Phil M. E
| Vickers, James C
| West, Adrian K
| Chuah, Meng Inn
Date: 2005
Subject Keyword:
Contusion
| Olfactory ensheathing cells
| Proliferation
| Spinal cord injury
| Stab wounds
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/225122
Description:
This study investigates proliferation and apoptosis of olfactory ensheathing cells in cocultures with spinal cord tissue. Proliferation of ensheathing cells was significantly increased when cocultured
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Authors:
Chung, Roger S
| Adlard, Paul A
| Dittmann, Justin
| Vickers, James C
| Chuah, Meng Inn
| West, Adrian K
Date: 2004
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/225163
Description:
Recent data suggests that metallothioneins (MTs) are major neuroprotective proteins within the CNS. In this regard, we have recently demonstrated that MT-IIA (the major human MT-I/-II isoform) promote
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Date: 2004
Subject Keyword:
Astrocyte
| Brain injury
| Growth inhibitory factor
| Ischemia
| Metallothionein
| Regeneration
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/225369
Description:
Metallothioneins (MTs) are small cysteine-rich proteins which are found widely throughout the mammalian body, including the CNS. There are extensive data on the structure and expression of MTs, and ma
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Date: 2003
Subject Keyword:
Cortical brain injury
| Metallothionein
| Neurite growth
| Neurite sprouting
| Reactive sprouting
| Wound healing
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/225179
Description:
Metallothioneins (MTs) are small, cysteine-rich, metal binding proteins. Their function has often been considered as stress-related proteins capable of protecting cells from heavy metal toxicity and o
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Authors:
Chung, Roger S
| Holloway, Adele F
| Eckhardt, Bedrich L
| Harris, Julie A
| Vickers, James C
| Chuah, Meng Inn
| West, Adrian K
Date: 2002
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/225203
Description:
Sheep metallothionein-III (MT-III) cDNA was isolated from a brain cDNA library and characterized. In contrast with MT-III from other species, sheep MT-III cDNA is predicted to encode a protein with si
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