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Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1194245
Description: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by extracellular plaques containing abnormal Amyloid Beta (Aβ) aggregates, intracellular neurofibrillary tangles cont ... More
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Reviewed: Reviewed
Date: 2015
Subject Keyword: aging | sirtuins | p53 | brain | longevity
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/355709
Description: Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their asso ... More
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Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: book chapter
Identifier: http://hdl.handle.net/1959.14/338039
Description: Glutamate was identified as the main excitatory neurotransmitter in the mammalian central nervous system (CNS) following the observation in the early 1950s that glutamate can induce seizure activity a ... More
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1018219
Description: Over the last decade, the importance of NAD⁺ has expanded beyond its role as an essential cofactor for energy metabolism. NAD⁺ has emerged as a major signalling molecule that serves as the sole substr ... More
Reviewed: Reviewed
Date: 2006
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/9206
Description: Indoleamine 2,3-dioxygenase is the first and rate limiting enzyme of the kynurenine pathway of tryptophan metabolism, has potent effects on cell proliferation and mediates antimicrobial, antitumorogen ... More
Reviewed: Reviewed
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