This chapter presents and evaluates a Web 2.0 Learning Design Framework that can be used to develop pre-service teachers' learning design capabilities. The framework integrates the TPACK model of educational practice, Anderson and Krathwohl's Taxonomy of learning, teaching and assessing, and different types of constructive and negotiated pedagogies, with a range of contemporary Web 2.0 based learning technologies. Pre-service teachers in a second year learning technology subject felt that the framework helped them to better understand the relationship between technology, pedagogy, and content, as well as create more effective learning designs for their students. Examples of student learning designs are used to illustrate the way that pre-service teachers applied the framework. Students' reflective responses to the framework are also used to explain how the Web 2.0 Learning Design Framework can be more effectively used to develop pre-service teachers' Web 2.0 learning design capabilities.